The Donor Cross-Specificity of Human Blood Group Aand B-Synthesizing Glycosyltransferases
Why this work is in the frame
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Bibliographic record
Abstract
The human ABO blood group is the most clinically significant blood group system and is certainly the best known. At its foundation are the genes coding for two glycosyltransferases which catalyze the transfer of distinct monosaccharides to a pre-existing acceptor structure (H) to form carbohydrate determinants distinguishing the A, B, and O(H) blood groups. Since the genes are thought to be co-dominant, the existence of the rare AB blood group has mainly been ascribed to the inheritance of both enzymes, a so-called trans-AB genotype. As the techniques of blood grouping have become more advanced however, the unusual genotypes cis-AB and B(A) have raised some interest, and the enzymes expressed by them are providing great opportunities for functionstructure studies on this highly important system.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it