Hypophosphatasia: Enzyme Replacement Therapy (Asfotase Alfa) Decreases TNSALP Substrate Accumulation And Improves Functional Outcomes In Affected Adolescents And Adults.
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
1Shriners Hospital for Children, St. Louis, MO USA; 2Duke University, Durham, NC; 3University of Manitoba, Winnipeg, Manitoba, Canada; 4Shriners Hospital, St. Louis, MO; 5University of Manitoba, Winnipeg, Manitoba, Canada; 6Alexion Pharmaceuticals, Cambridge, MA; 7Corresponding Author: Nerissa Kreher, MD, Alexion Pharmaceuticals, 55 Cambridge Parkway, Ste 800, Cambridge,MA 02142 USA, 617-674-5739; email:Nerissa.Kreher@alxn.com Whyte MP1, Kishnani PS2, Greenberg CR3, Madson K4, Mack K4, Weber T2, Mhanni A5, Plotkin H6, Kreher N6, Landy H6, Nerissa Kreher7 SHORT COMMUNICATION
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.002 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it