Unexpected posthemorrhagic hydrocephalus in patients treated with rFVIIa
Bibliographic record
Abstract
One-third of patients with intracerebral hemorrhage (ICH) are dead within 1 month of symptom onset, and only 20% regain functional independence.1 In a recent Phase IIB study, recombinant Factor VIIa (rFVIIa) given within 4 hours after the onset of ICH significantly reduced hematoma growth and improved clinical outcomes; this effect is being evaluated in a Phase III trial.2 Enthusiasm for the use of rFVIIa is tempered by safety concerns. An increased frequency of thromboembolic complications, notably arterial ischemic events, among patients with ICH treated with rFVIIa has been observed. We report our open-label experience with rFVIIa used within an institution-approved protocol and the occurrence of posthemorrhagic hydrocephalus as an unexpected complication. rFVIIa was administered at a dose of 40 μg/kg body weight to nine patients with ICH diagnosed by CT scan within 3 hours from symptom onset. The inclusion and exclusion criteria for administration of rFVIIa were …
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.003 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".