T<sub>1</sub>, T<sub>2</sub> relaxation and magnetization transfer in tissue at 3T
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Abstract
T1, T2, and magnetization transfer (MT) measurements were performed in vitro at 3 T and 37 degrees C on a variety of tissues: mouse liver, muscle, and heart; rat spinal cord and kidney; bovine optic nerve, cartilage, and white and gray matter; and human blood. The MR parameters were compared to those at 1.5 T. As expected, the T2 relaxation time constants and quantitative MT parameters (MT exchange rate, R, macromolecular pool fraction, M0B, and macromolecular T2 relaxation time, T2B) at 3 T were similar to those at 1.5 T. The T1 relaxation time values, however, for all measured tissues increased significantly with field strength. Consequently, the phenomenological MT parameter, magnetization transfer ratio, MTR, was lower by approximately 2 to 10%. Collectively, these results provide a useful reference for optimization of pulse sequence parameters for MRI at 3 T.
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The record
- Venue
- Magnetic Resonance in Medicine
- Topic
- Advanced MRI Techniques and Applications
- Field
- Medicine
- Canadian institutions
- Hospital for Sick ChildrenHealth Sciences CentreUniversity of TorontoSunnybrook Health Science Centre
- Funders
- —
- Keywords
- Magnetization transferRelaxation (psychology)Nuclear magnetic resonanceMagnetizationPulse sequenceWhite matterMagnetic relaxationSpin–lattice relaxationChemistryPhysicsMagnetic resonance imagingMagnetic fieldBiologyMedicine
- Has abstract in OpenAlex
- yes