A practical guide to arylbiguanides Synthesis and structural characterization
Why this work is in the frame
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Bibliographic record
Abstract
Monohydrochloride salts of diverse 1-arylbiguanides and 1,5-diarylbiguanides were synthesized by the reaction of anilinium chlorides with dicyandiamide or sodium dicyanamide, and the biguanidinium chlorides were converted into the corresponding biguanides by deprotonation with methanolic NaOCH 3 . The resulting biguanides and their salts were fully characterized by spectroscopic methods, and the structures of representative compounds were determined by X-ray crystallography.Key words: biguanide, biguanidinium, synthesis, structure, hydrogen bonds, noncovalent interactions, supramolecular chemistry.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.004 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it