Cytochrome P450 1A and related measurements in juvenile chinook salmon (<i>Oncorhynchus tshawytscha</i>) from the Fraser River
Bibliographic record
Abstract
Juvenile chinook salmon (Oncorhynchus tshawytscha) were captured at six sites on the upper Fraser, Nechako, and Thompson rivers, British Columbia, Canada. Biological responses were measured in the liver to assess the effects of contaminants on the fish before they began migration downstream. Both ethoxyresorufin-O-deethylase (EROD) activity and CYP 1A concentrations were significantly enhanced, being two- to three-fold higher in Fraser River samples compared with those fish from reference sites on the Nechako River. DNA adduct concentrations were two- to four-fold higher in Fraser River fish, although liver histopathology appeared unaffected. Polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and polychlorinated biphenyls (PCBs) in the carcasses contributed to total contaminant burdens of less than 1 pg·g-1. Polycyclic aromatic hydrocarbon (PAH) metabolites were undetectable in nearly all samples of bile. There were strong correlations between EROD activity, CYP 1A induction, and DNA adduct concentrations but no clear correlation between these responses and PCDD, PCDF, or PCB concentrations.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".