Incomplete recovery of endplate potential amplitude while intermittently activating rat soleus neuromuscular junctions in situ
Bibliographic record
Abstract
Studies dealing with neuromuscular transmission efficacy typically employ continuous patterns of activation to demonstrate decrements in endplate potential (epp) amplitude. Recent evidence from rat diaphragm muscle has shown that including periods of quiescence to the stimulation protocol allows epp amplitude to recover between series of contractions. Whether similar recovery occurs in rat hindlimb muscle is unknown. In this study, we have measured declines in epp amplitude in rat soleus muscle during trains of stimulation evoked either continuously (10 s) or intermittently (400 ms repeated every second), using an in situ approach. As in diaphragm, we found that rest periods within the intermittent trains significantly improved neuromuscular transmission efficacy. However, unlike the diaphragm, epp amplitude recovery was incomplete even by the second train in the intermittent protocols, recovery being frequency-dependent and ranging from 40 to 50%. The results suggest that the kinetics of epp amplitude rundown and recovery may be muscle-specific, and should be considered when evaluating situations in which neuromuscular transmission efficacy may be altered.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".