812 INTERSTITIAL CYSTITIS/PAINFUL BLADDER SYNDROME: EFFECTS OF AGE AND GENDER
Bibliographic record
Abstract
You have accessJournal of UrologyInfections/Inflammation of the Genitourinary Tract: Interstitial Cystitis1 Apr 2011812 INTERSTITIAL CYSTITIS/PAINFUL BLADDER SYNDROME: EFFECTS OF AGE AND GENDER Lee Jonat and Joel Teichman Lee JonatLee Jonat Vancouver, Canada More articles by this author and Joel TeichmanJoel Teichman Vancouver, Canada More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2011.02.630AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES To determine whether interstitial cystitis/painful bladder (IC/PBS) patients present differently by age; whether IC/PBS patients present differently by gender; and whether IC/PBS patients who satisfy NIDDK criteria differ from patients who do not satisfy NIDDK criteria. METHODS Consecutive IC/PBS subjects (89 men and 387 women) were studied retrospectively. Clinical data were collected prospectively, including frequency, nocturia, exam findings, voided volumes, validated instrument scores, and cystoscopy hydrodistension findings. Subjects were divided into cohorts and contrasted: by age quartiles; male versus female subjects; and NIDDK criteria versus non-NIDDK criteria diagnosed subjects. RESULTS Younger subjects had less nocturia, and larger anesthetic capacity vs older subjects (Table 1). Men and women presented similarly for frequency, nocturia, pain, triggers, voided volumes, glomerulations, and Hunner's ulcers. They differed for IBS, prior sex abuse, prior urinary infection diagnoses, suprapubic tenderness on exam, and anesthetic capacity (Table 2). Subjects who satisfied NIDDK criteria were older, had more severe symptoms, smaller voided volumes, and smaller anesthetic capacities than non-criteria subjects (Table 3). IC/PBS DISEASE PROGRESSION WITH AGE 1st quartile (14-31 years) 2nd quartile (32-40 years) 3rd quartile (41-52 years) 4th quartile (53-90 years) p-value Duration (years) 3±3 5±6 6±7 9±13 <0.001 Nocturia 2±2 2±2 3±2 4±3 <0.001 Frequency (hrs between voids) 1.3±0.9 1.2±0.8 1.3±1.5 1.2±0.8 0.70 PUF 18±6 18±7 19±7 19±7 0.72 ICSI 9±3 9±4 10±4 10±4 0.03 ICPI 10±4 10±4 11±4 11±4 0.01 Voided volume (cc) 125±88 135±93 132±128 120±96 0.54 Cysto hydro capacity (cc) 788±245 826±249 692±296 526±249 <0.01 Glomerulations 56% 46% 60% 51% 0.75 Hunner's ulcers 3% 0% 4% 20% <0.01 SIMILARITIES/DIFFERENCES BETWEEN MEN AND WOMEN PRESENTING WITH IC/PBS Men Women p-value Age (years) 45±13 42±15 0.05 Duration symptoms (years) 6±6 7±7 0.4 Frequency (hrs between voids) 1±1 1±1 0.4 Nocturia 3±2 2±2 0.51 Prior diagnosis recurrent UTIs 1% 25% <0.001 Concomitant IBS 3% 29% <0.001 Childhood sex abuse 0% 11% <0.01 Suprapubic area tender to palpation 8% 43% <0.001 ICSI 9±4 9±4 0.41 ICPI 9±5 10±4 0.07 PUF 19±7 17±7 0.01 Voided volumes (cc) 122±78 110±108 0.47 Anesthetic hydrodistenstion capacity (cc) 652±256 780±275 0.03 Glomerulations 43% 60% 0.15 Hunner's ulcers 8% 12% 0.73 NIDDK versus non-NIDDK criteria patients NIDDK criteria non-NIDDK criteria p-value Age (years) 45±18 37±13 <0.01 Nocturia 4±2 2±2 0.001 Frequency (hours between voids) 0.9±0.8 1.4±0.9 <0.001 Voided volumes (cc) 116±76 175±92 <0.001 ICSI 11±4 9±4 0.01 ICPI 12±3 10±4 <0.05 anesthetic hydrodistension capacity (cc) 562±188 986±136 <0.001 CONCLUSIONS IC/PBS presents with worse disease as patients age. Men and women with IC/PBS present similarly. Patients who satisfy NIDDK criteria define a more symptomatic and severe disease compared to patients who do not satisfy NIDDK criteria. A high index of suspicion is required to diagnose male and younger IC/PBS patients. © 2011 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 185Issue 4SApril 2011Page: e326-e327 Peer Review Report Advertisement Copyright & Permissions© 2011 by American Urological Association Education and Research, Inc.MetricsAuthor Information Lee Jonat Vancouver, Canada More articles by this author Joel Teichman Vancouver, Canada More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.005 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".