Anemia in Spontaneously Type 2 Diabetic Rats With Renal Impairment
Bibliographic record
Abstract
Background: The eSS rats display a mild non obese type 2 diabetic syndrome with an insulin resistant state characterized by hyperglycemia, dyslipidemia and hyperinsulinemia. During the first year, eSS male rats exhibit proteinuria as well as alterations in glomerular filtration. Methods: In this study, some hematological characteristics were evaluated in 12 month-old eSS males compared to eumetabolic Wistar rats, and the renal histology was also studied. Results: The diabetic rats were found to have fewer erythrocytes and lower values ??of hemoglobin. In eSS rats, peripheral blood smears showed immature erythrocytes with polychromatophilia and the presence of erythroblasts was also verified. Thickening of the glomerular basement membrane, areas of tubular dilatation and protein cylinders were observed in kidneys of diabetic animals. Conclusions: Our results suggest that eSS rats develop anemia because of complex influences of metabolic disturbances and diabetic renal damage and that it might provide new opportunities for studying the pathogenesis of this relevant complication of type 2 diabetics. doi: http://dx.doi.org/10.4021/jem122w
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".