Bibliographic record
Abstract
ACE2 is a recently identified homologue of ACE that has been shown to cleave Ang I to Ang 1-9, which can subsequently be cleaved to Ang 1-7, a potent vaso-depressor peptide. We hypothesize that loss of ACE2 expression leads to a decrease in Ang 1-7, causing an imbalance of pressor/depressor peptide levels and an increase in systemic arterial pressure. We have independently cloned rat ACE2. Radiation hybrid mapping placed ACE2 on the X chromosome within a defined QTL identified by positional cloning in the Sabra salt-sensitive model of hypertension. Overlapping QTLs have also been identified in SHRSP and SHR rats models of hypertension. ACE2 expression, measured by Northern analysis, was diminished in hypertensive SBH/y (35± 10% of control, N=4) compared to normotensive SBN/y. Western blotting with an ACE2 antibody revealed similar reduction in levels of ACE2 protein (48± 13% in SBH/y compared to SBN/y, N=4) and in SHR and SHRSP (51± 2.5% of control, N=4) compared to normotensive WKY. The experimental data obtained thus far lend support to a novel mechanism for hypertension according to which: (1) ACE2 is a regulator of vascular tone that counterbalances ACE activity, and that (2) in the presence of reduced ACE2 expression and vaso-depressor peptide levels, ACE activity predominates, leading to increased vascular tone and consequently hypertension. ACE2 is thus a novel candidate gene for hypertension.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.004 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".