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Record W2023733459 · doi:10.1159/000179684

Influence of the Pineal Gland on Hypothalamic Content of TRH in the Syrian Hamster

2008· article· en· W2023733459 on OpenAlex

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.

Bibliographic record

VenueHormone Research · 2008
Typearticle
Languageen
FieldNeuroscience
TopicRegulation of Appetite and Obesity
Canadian institutionsUniversity of Manitoba
Fundersnot available
KeywordsPinealectomyInternal medicineEndocrinologyPineal glandHypothalamusThyroidHamsterThyrotropin-releasing hormoneBasal (medicine)HormoneEndocrine glandBiologyMedicineMelatonin

Abstract

fetched live from OpenAlex

Blinding adult female hamsters by bilateral orbital enucleation caused an increase in thyrotropin-releasing hormone (TRH) content of the medial basal hypothalamus and also led to an increase in TRH content in the remainder of the hypothalamus (dorsal hypothalamus). Although pinealectomy by itself had no significant effect on the neuroendocrine-thyroid axis, this surgical procedure prevented the inhibition of serum thyroxin observed in blinded hamsters. Pinealectomy also prevented the increase in TRH content of medial basal and dorsal hypothalamus observed in blinded hamsters. The results are consistent with the view that the pineal gland has a CNS site of action and provide evidence that the anti-thyroid influence of the pineal gland can be explained by pineal inhibition of TRH release.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.675
Threshold uncertainty score0.208

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.001
Science and technology studies0.0000.001
Scholarly communication0.0000.000
Open science0.0010.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.187
GPT teacher head0.340
Teacher spread0.153 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it