An <i>MBoC</i> Favorite: Class VI unconventional myosin is required for spermatogenesis in <i>Drosophila</i>
Bibliographic record
Abstract
In celebration of MBoC's first 20 years, members of the Editorial Board, members of the ASCB Council, and others comment on their favorite MBoC papers from the past two decades.This paper is a beautiful example of how studies in Drosophila melanogaster can reveal unexpected functions of conserved proteins in multicellular organisms.Drosophila spermatogenesis takes place within a syncytial cytoplasm.At the end of spermatogenesis, individualization complexes (ICs) containing F-actin traverse the length of the spermatid cysts, reorganizing membranes and removing material not required in mature sperm.Previous experiments had implicated myosin VI in cellularization of the syncytial embryo.However, since mutations in the gene encoding myosin VI were unavailable, its in vivo functions were poorly understood.Hicks et al. (1999) isolated partial loss-offunction mutations in myosin VI and demonstrated that the incorporation of myosin VI at the leading edge of ICs is necessary to form the robust F-actin arrays required for proper IC movement and individualization.This laid the groundwork for subsequent studies (many in MBoC) dissecting myosin VI function in vivo, thereby illuminating principles that apply to a variety of specialized cells.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.006 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.002 | 0.002 |
| Scholarly communication | 0.004 | 0.002 |
| Open science | 0.002 | 0.002 |
| Research integrity | 0.006 | 0.009 |
| Insufficient payload (model declined to judge) | 0.004 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".