Endoplasmic reticulum proteins in cardiac development and dysfunction
Bibliographic record
Abstract
An understanding of cardiac pathologies and the molecular mechanisms thereof is essential for the development of therapies for cardiovascular disease, a common cause of death in Western societies. Investigations into heart diseases have shown that the endoplasmic reticulum and its diverse functions may lie at the center of many cardiac pathologies. Animal models have demonstrated that in numerous cases, faulty endoplasmic reticulum activity is manifested in defective cardiogenesis or impaired heart function. These findings suggest that the endoplasmic and sarcoplasmic reticulum membranes may represent functionally independent organelles responsible for specialized functions in the heart. This review addresses the molecular pathways linking endoplasmic reticulum function and malfunction with impaired cardiac phenotypes. The endoplasmic reticulum affects cardiac development and function through Ca2+-dependent pathways, its catalytic role in the proper folding and targeting of membrane-bound and secretory proteins, and its response to cellular stress events, particularly hypoxic conditions. These pathways present potential novel targets for treatment of cardiac disease.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.004 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".