Bibliographic record
Abstract
Abstract Membranous nephropathy (MN) is an important glomerular disease characterized by podocyte injury and protein‐uria. The understanding of cellular and molecular mechanisms involved in the pathogenesis of MN has come from studies in the Heymann nephritis model of MN in the rat. MN involves the in situ formation of subepithelial immune deposits of antibodies reactive to podocyte antigens, activation of complement, and assembly of C5b‐9 on podo‐cyte plasma membranes. The podocyte responds to C5b‐9 attack by activating protein kinases, phospholipases, oxidants, transcription factors, growth factors, stress pathways, proteinases, and other mediators. These signals impact on metabolic pathways, structure/function of lipids, proteins in the cytoskeleton and slit diaphragm, and turnover of extracellular matrix components. Some effects of C5b‐9 affect podocyte functions adversely, while other effects may limit injury or promote recovery. Increased understanding of pathogenic antigens, complement activation, and changes in podocyte biology induced by C5b‐9 is an opportunity for new diagnostic and concept‐driven therapeutic approaches to this disease.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.001 | 0.002 |
| Scholarly communication | 0.003 | 0.003 |
| Open science | 0.001 | 0.002 |
| Research integrity | 0.002 | 0.004 |
| Insufficient payload (model declined to judge) | 0.005 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".