An Extract from North American Ginseng Stimulates Spontaneous Immunity in Infant Mice: Sustained, Augmented Immunity in Adulthood Long after Withdrawal of the Extract
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
The present study evaluated the effect of CVT E002, a proprietary extract of North American ginseng, Panax quinquefolius (CV Technologies, Inc., Edmonton, AB, Canada), in vivo, on the hemopoietic and immune cells when administered intraperitoneally to infant (pre-weaned) mice. The extract was administered to groups of mice daily, for 14 days, from 7 21 days after birth, the dosage being adjusted progressively according to body weight as the infants grew. At 21-26 days of age, the period immediately after the last of the injection, and at 7-8 weeks of age, long after the termination of CVT E002, the bone marrow and spleen were removed from treated and control mice (CVT E002-injected and vehicle-injected, respectively). The results revealed that CVT E002 stimulated only those cells acting as the first line of defense against cancer, i.e., natural killer (NK) cells and granulocytes when assessed immediately after termination of CVT E002. However, even more potentially significant, was the observation that in spite of withdrawing the agent at weaning (21 days of age), the influence of CVT E002 had indirectly continued to produce a significant augmentation in NK cells and granulocytes in adulthood. Thus, CVT E002 may be considered as a dietary additive, fortifying anti-cancer immunity during the critical infant/juvenile ages when, in humans at least, pediatric cancers such as leukemia, lymphomas, Wilms tumors and retinoblastoma are relatively frequent.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it