The Use of UV-Cross-Linkable Di-Block Copolymers as Functional Reaction Surfaces for Microelectrode Arrays
Bibliographic record
Abstract
Three types of UV-cross-linkable di-block copolymers have been developed as coatings for microelectrode arrays. All three polymers share the same PCEMA block for the cross-linking reaction. The PBrSt-b-CEMA polymer was shown to be compatible with a series of Pd(0)- and Cu(I)-catalyzed reactions. It was compatible with electrochemical signaling experiments, although it showed non-specific binding to proteins at higher concentrations. In order to study weak binding interactions, PCEMA-b-PPEGMA was developed to reduce non-specific binding. However, it was shown not to be a stable enough surface for array-based reactions. In an effort to make a tunable surface, PCEMA-b-BSt was made and was shown to be compatible with Suzuki reactions on the array, however, the inability of achieving a stable current deemed it incompatible with signaling experiments. The use of a pinacol protected PCEMA-b-pBSt polymer solved these issues. The protected polymer could be site-selectively deprotected, transesterified, and functionalized with Cu(II)-catalyzed reactions. It is also compatible with the electrochemical impedance experiments used to signal binding events on the arrays.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".