Chemical Modification of Chitosan. 10. Synthesis of Dendronized Chitosan−Sialic Acid Hybrid Using Convergent Grafting of Preassembled Dendrons Built on Gallic Acid and Tri(ethylene glycol) Backbone
Why this work is in the frame
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Bibliographic record
Abstract
Sialic acid dendrons bearing a focal aldehyde end group were synthesized by a reiterative amide bond strategy. Polyamine-ending trivalent ( G = 1) and nonavalent ( G = 2) dendrons having gallic acid as branching unit and tri(ethylene glycol) as spacer arm were prepared and initially attached to a sialic acid p- phenylisothiocyanate derivative. The focal aldehyde sialodendrons were then convergently grafted onto the polysaccharide chitosan backbone by reductive amination in 76−80% yields. The degrees of substitution (DS) of the sialodendrimer in the hybrids were 0.13 ( G = 1) and 0.06 ( G = 2), which indicates that 87% and 40% of the sialodendrons were attached to the primary amino groups of chitosan. The water solubility of these novel hybrids was further improved by N-succinylation of the remaining amine functionality.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it