Rapid Remission of a Second Primary Kaposi’s Sarcoma With Thalidomide Treatment in a Patient Receiving Adjuvant Chemotherapy for Colon Cancer
Bibliographic record
Abstract
Kaposi’s sarcoma is a human herpes virus 8 associated-angioproliferative disorder, which is commonly associated with immunocompromised conditions such as those which arise in renal transplant recipients, or in acquired immune-deficiency syndrome (AIDS) cases. It is less well described, however, in patients with solid tumors undergoing adjuvant chemotherapy after surgery. We report the case of an HIV-negative heterosexual Taiwanese man who developed a second primary Kaposi’s sarcoma 5 months after the start of adjuvant chemotherapy for stage III colon cancer. Thalidomide treatment was started after the patient completed 6 months of adjuvant chemotherapy, and the Kaposi’s sarcoma regressed within 2 months. The case reported here suggests that pre-existing HHV-8 infection and adjuvant chemotherapy may predispose these patients to a second malignancy with Kaposi’s sarcoma. Restoration of immune function through cessation of chemotherapy and thalidomide administration may accelerate the regression of the disease, thereby avoiding the need for radiotherapy or anthracycline-based chemotherapy. J Med Cases. 2013;4(7):466-470 doi: https://doi.org/10.4021/jmc1199w
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.002 | 0.002 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".