Rejection of Tumor Cells in vitro: Morphological Studies on Killer T Cells and Damaged Tumor Cells
Bibliographic record
Abstract
The in vitro destruction of a methylcholanthrene-induced guinea pig sarcoma (MC-D) by killer T lymphocytes was investigated by light and electron microscopy. Various degrees of cell damage ranging from slight to extensive were observed. In cells with slight injury, dilatation, vesiculation, fragmentation and degeneration of the rough surfaced endoplasmic reticulum were the most characteristic findings. In cells with extensive injury, widespread nuclear and cytoplasmic alterations were evident and many of these cells were fragmented into smaller portions and finally transformed into granular membranous and amorphous debris. Cytoplasmic vacuoles filled with electron-lucent material were frequent in extensively damaged cells. Killer lymphocytes resembled closely antibody-forming plasma cells when examined with light microscopy but lacked the extensive network of rough surfaced endoplasmic reticulum, and did not produce immunoglobulin. It is suggested that these extensively differentiated T-derived killer cells are end cells similar to those of B lymphocyte-derived plasma cells. Viral particles resembling closely C-type viruses were observed in mixed killer cell MC-D cultures.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".