Sustained proliferation in cancer: Mechanisms and novel therapeutic targets
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Abstract
Proliferation is an important part of cancer development and progression. This is manifest by altered expression and/or activity of cell cycle related proteins. Constitutive activation of many signal transduction pathways also stimulates cell growth. Early steps in tumor development are associated with a fibrogenic response and the development of a hypoxic environment which favors the survival and proliferation of cancer stem cells. Part of the survival strategy of cancer stem cells may manifested by alterations in cell metabolism. Once tumors appear, growth and metastasis may be supported by overproduction of appropriate hormones (in hormonally dependent cancers), by promoting angiogenesis, by undergoing epithelial to mesenchymal transition, by triggering autophagy, and by taking cues from surrounding stromal cells. A number of natural compounds (e.g., curcumin, resveratrol, indole-3-carbinol, brassinin, sulforaphane, epigallocatechin-3-gallate, genistein, ellagitannins, lycopene and quercetin) have been found to inhibit one or more pathways that contribute to proliferation (e.g., hypoxia inducible factor 1, nuclear factor kappa B, phosphoinositide 3 kinase/Akt, insulin-like growth factor receptor 1, Wnt, cell cycle associated proteins, as well as androgen and estrogen receptor signaling). These data, in combination with bioinformatics analyses, will be very important for identifying signaling pathways and molecular targets that may provide early diagnostic markers and/or critical targets for the development of new drugs or drug combinations that block tumor formation and progression.
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The record
- Venue
- Seminars in Cancer Biology
- Topic
- Cancer-related Molecular Pathways
- Field
- Medicine
- Canadian institutions
- —
- Funders
- National Cancer InstituteEuropean Regional Development FundNational Institutes of HealthJunta de Castilla y LeónEuropean CommissionMinisterio de Ciencia e InnovaciónMinistero dell’Istruzione, dell’Università e della RicercaMinistero della SaluteTerry Fox FoundationEuropean Cooperation in Science and TechnologyUniversity of GlasgowConsejería de Educación, Junta de Castilla y LeónNational Institute of Allergy and Infectious DiseasesAl Jalila FoundationMinistry of Education, Culture, Sports, Science and TechnologyUnited Arab Emirates UniversityCancer Research UKPurdue UniversityAvon Foundation for WomenPurdue University Center for Cancer ResearchNational Institute of Diabetes and Digestive and Kidney DiseasesTemple UniversityFederación Española de Enfermedades RarasAmerican Cancer SocietyUniversità degli Studi Roma TreCenter for Hierarchical Manufacturing, National Science FoundationBreast Cancer Research FoundationAssociazione Italiana per la Ricerca sul CancroNational Science Foundation
- Keywords
- BiologyWnt signaling pathwayCancer researchProtein kinase BCancer stem cellSignal transductionStromal cellCell growthCancer cellCancerAngiogenesisCell cycleCell biologyStem cellBiochemistry
- Has abstract in OpenAlex
- yes