A Multistep Synthesis for an Advanced Undergraduate Organic Chemistry Laboratory
Why this work is in the frame
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Bibliographic record
Abstract
A three-step procedure appropriate for an advanced-level undergraduate organic chemistry laboratory course has been developed for the synthesis of 5-(2-sulfhydrylethyl)salicylaldehyde. Two compounds, namely, 4-(2-iodoethyl)phenol and 5-(2-iodoethyl)salicylaldehyde, are isolated as intermediates from the first two steps of the method. A Grignard reagent is employed as a critical reactant for the synthesis. Several important laboratory techniques, such as TLC, column chromatography, and recrystallization, are emphasized. Spectrometric methods, including GC–MS and NMR spectroscopy, are used to identify the final product as well as the intermediates. Since each step of the procedure involves two or more hours of refluxing, parts of this experiment can be interspersed with other laboratory activities.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it