Two's company, three's a crowd: can H <sub>2</sub> S be the third endogenous gaseous transmitter?
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- Teacher spread
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- Validation status
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Abstract
Bearing the public image of a deadly "gas of rotten eggs," hydrogen sulfide (H2S) can be generated in many types of mammalian cells. Functionally, H2S has been implicated in the induction of hippocampal long-term potentiation, brain development, and blood pressure regulation. By acting specifically on KATP channels, H2S can hyperpolarize cell membranes, relax smooth muscle cells, or decrease neuronal excitability. The endogenous metabolism and physiological functions of H2S position this gas well in the novel family of endogenous gaseous transmitters, termed "gasotransmitters." It is hypothesized that H2S is the third endogenous signaling gasotransmitter, besides nitric oxide and carbon monoxide. This positioning of H2S will open an exciting field-H2S physiology-encompassing realization of the interaction of H2S and other gasotransmitters, sulfurating modification of proteins, and the functional role of H2S in multiple systems. It may shed light on the pathogenesis of many diseases related to the abnormal metabolism of H2S.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
The record
- Venue
- The FASEB Journal
- Topic
- Sulfur Compounds in Biology
- Field
- Biochemistry, Genetics and Molecular Biology
- Canadian institutions
- University of Saskatchewan
- Funders
- —
- Keywords
- TransmitterEndogenyEnvironmental scienceChemistryBusinessTelecommunicationsComputer scienceBiochemistryChannel (broadcasting)
- Has abstract in OpenAlex
- yes