Lack of Therapeutic Effect of a Specially Designed Yogurt for the Eradication of <i>Helicobacter pylori</i> Infection
Why this work is in the frame
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Bibliographic record
Abstract
<i>Background:</i> Current antibiotic treatment for <i>Helicobacter pylori</i> infection is often associated with frequent adverse effects and resistance to antibiotics. Alternative treatment methods to control <i>H. pylori</i> infection are needed. Some specific strains of lactic acid bacteria (probiotics) in dairy products are known to inhibit the growth of <i>H. pylori </i>in vitro. A clinical trial was conducted to see the efficacy of a specially designed yogurt product containing specific probiotics on the eradication of <i>H.</i><i>pylori</i>. <i>Method:</i> The yogurt was prepared using three <i>Lactobacillus</i> spp. (<i>L. acidophilus</i> and <i>L. casei</i>) and one commercial starter culture (<i>L. acidophilus</i>, <i>L. bulgaricus</i> and <i>Streptococcus thermophilus</i>). All these cultures were previously evaluated, and found to have strong in vitro inhibitory effects on the growth of <i>H. pylori</i>. Twenty-seven asymptomatic women positive for <i>H. pylori</i> on gastric biopsy and <sup>13</sup>C urea breath test were recruited, and administered 175 ml of the yogurt three times a day for 30 days. The <sup>13</sup>C urea breath test was administered again, one month after stopping the yogurt treatment to detect the presence of <i>H. pylori.</i><i>Results:</i> In 26 of 27 subjects, the urea breath test values remained positive, indicating that the consumption of the yogurt had no effect on the eradication of<i> H. pylori</i>. <i>Conclusion</i>: Although the designed fermented milk containing lactobacilli is very effective in the inhibition of <i>H. pylori </i>growth in vitro, eradication of this infection in humans is difficult to achieve by consuming this product.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it