Excitation-Contraction Coupling in Heart
Bibliographic record
Abstract
On perfusing the isolated rat heart with a medium containing Ca45, mitochondrial fraction was found to contain more radioactivity than sarcoplasmic reticulum. Not only the calcium contents of mitochondria were higher but also the specific activity of calcium pool of mitochondria was greater than that of the sarcoplasmic reticulum. The in vitro studies revealed that during 10 min of incubation mitochondria accumulated more calcium and hydrolyzed less ATP in comparison to the sarcoplasmic reticulum. Calcium accumulation and ATP hydrolysis by mitochondria were markedly inhibited by 5 mMazide. On the other hand, azide had a slight inhibitory action on the ATPase activity of sarcoplasmic reticulum but did not influence its ability to bind calcium. On the basis of 1 min calcium binding values, total mitochondria and sarcoplasmic reticulum present in the heart are considered to accumulate 0.395 and 0.085 µmol of calcium/g of heart. It is suggested that free calcium concentration in the heart is determined mainly by the activities of mitochondria, sarcoplasmic reticulum, contractile proteins and movements across the cell membrane.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".