The in vitro isolation and characterization of monosomic sublines derived from a Colcemid-treated Chinese hamster cell population
Bibliographic record
Abstract
A series of 18 sublines deficient for one or two chromosomes was isolated in vitro from a pseudodiploid Chinese hamster cell population treated appropriately with Colcemid to obtain maximal induction of aneuploidy. Chromosomes 10 and 11 were the most frequently involved and, to a lesser extent, chromosome 9 and the partially deleted 6. Since analysis of chromosome banding patterns did not reveal any evidence of chromosome rearrangement, it was concluded that entire chromosomes were absent, and thus the sublines are presumed to be monosomic. The monosomic state was quickly lost during serial culture, and the 15th passage after isolation, the monosomic cell type accounted for less than 50% of the cell population in over half the sublines. This was due to a shift in chromosome number back to 22, apparently by reacquistion of the absent chromosome, or to the appearance of tetraploidy.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".