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Record W2029771706 · doi:10.1016/j.bbagrm.2010.05.002

Conformational coupling, bridge helix dynamics and active site dehydration in catalysis by RNA polymerase

2010· article· en· W2029771706 on OpenAlexafffund
Steve Seibold, Badri Nath Singh, Chunfen Zhang, Maria L. Kireeva, Céline Domecq, Annie Bouchard, Anthony M. Nazione, Michael Feig, Robert I. Cukier, Benoit Coulombe, Mikhail Kashlev, Michael Hampsey, Zachary F. Burton

Bibliographic record

VenueBiochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · 2010
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicProtein Structure and Dynamics
Canadian institutionsMontreal Clinical Research Institute
FundersNational Institute of General Medical SciencesCanadian Institutes of Health Research
KeywordsHelix (gastropod)Dynamics (music)PolymeraseChemistryBiophysicsCoupling (piping)Active siteMolecular dynamicsBridge (graph theory)CatalysisBiochemistryBiologyPhysicsMaterials scienceComputational chemistryDNAEcology

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.013
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.003
GPT teacher head0.215
Teacher spread0.212 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations42
Published2010
Admission routes2
Has abstractno

Explore more

Same venueBiochimica et Biophysica Acta (BBA) - Gene Regulatory MechanismsSame topicProtein Structure and DynamicsFrench-language works237,207