Increased Intracavernosal Pressure Response in Hypertensive Rats After Chronic Hemin Treatment
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
INTRODUCTION: Erectile dysfunction (ED) is increased in prevalence in patients with arterial hypertension. Whether upregulation of heme oxygenase (HO) expression could improve penile erection has been unknown. AIMS: To correlate altered expression profiles of HO-1 and soluble guanylyl cyclase (sGC) in penile tissues with low intracavernosal pressure (ICP) in adult spontaneously hypertensive rats (SHR); and to investigate therapeutic effect of hemin-induced upregulation of HO-1 in penile tissues on ED developed in adult SHR. METHODS AND MAIN OUTCOME MEASURES: Intracavernosal pressure changes after electrical stimulation were monitored in adult SHR and age-matched normotensive Sprague-Dawley (SD) rats after chronic administration of either hemin or hydralazine. Expression levels of HO-1, HO-2, sGC, and phosphodiesterase type 5 (PDE5) were examined with Western blot. RESULTS: Frequency-dependent ICP changes were reduced in adult SHR. Three weeks after hemin treatment, high blood pressure of SHR was normalized and ICP responses to electrical stimulations in SHR were significantly increased to the level of normotensive rats. Hydralazine-treated SHR had normalized blood pressure but unaltered low ICP response. Expression of HO-1 and sGC was upregulated and that of PDE5 downregulated in hemin-treated, but not hydralazine-treated, SHR. CONCLUSIONS: Decreased erectile responses in adult SHR can be improved through chronic hemin treatment. Prolonged upregulation of HO-1 and sGC as well as lowered expression of PDE5 may at least partially explain the effect of hemin treatment on ICP. Upregulation of HO-1 may represent a novel therapeutic approach to treat ED.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it