Patterns of Amino-acid Inhibition of Alkaline Phosphatases as an Aid in Cancer Diagnosis
Bibliographic record
Abstract
(1) The amino acid inhibition of alkaline phosphatases is a concentration-dependent, reversible process. (2) Isoenzymes from different organs and tumours have definite and reproducible patterns of amino acid inhibition in vitro. The use of 5 different amino acids (l-Phe, l-Arg, l-Homoarg, l-Met and l-Val) made it possible to establish such a pattern. (3) The enzymes in tumours are more sensitive to amino acid inhibition in vitro than those in their corresponding normal tissues. Different tumours show different amino acid inhibition patterns; there is no common tumoui type of alkaline phosphatase according to this criterion. (4) In the enzyme mixtures such as are found in human serum (unless one variant is present in an unusually high proportion) the individual components seems to influence mutually their respective characteristics in such a way that single variants cannot be distinguished, or their source traced with certainty.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".