Patient Care and Treatment in Amyotrophic Lateral Sclerosis
Bibliographic record
Abstract
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the loss of upper and lower motor neurons, leading to limb paralysis and respiratory failure. ALS is considered as an incurable disease. However, the management has considerably changed for recent years. Currently, four crucial sections of practice and treatment have been recommended for prolonging the survival of ALS patients: 1) symptomatic treatment; 2) respiratory management; 3) nutritional management; and 4) disease modifying medication. Although many clinical symptoms occur during the disease course, those symptoms are treatable in ALS patients. All efforts should be made to improve quality of life and to assist in keeping the patient ’ s autonomy. Advanced directives on end of life care, respiratory and nutritional management during late stages of life are important issues. This review article introduces current treatment, including symptomatic treatments, ventilation, nutrition, disease modifying medication or condition in ALS patients, including riluzole, serum levels of cholesterol, urate and ferritin, and clinical therapeutic trials. doi: http://dx.doi.org/10.4021/jnr176w
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.004 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.002 |
| Research integrity | 0.002 | 0.002 |
| Insufficient payload (model declined to judge) | 0.007 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".