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Record W2030990090 · doi:10.1109/isb.2012.6314134

New global stability conditions for genetic regulatory networks with time-varying delays

2012· article· en· W2030990090 on OpenAlexaff
Li‐Ping Tian, Shi Zhong-ke, Fang‐Xiang Wu

Bibliographic record

Venuenot available
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGene Regulatory Network Analysis
Canadian institutionsUniversity of Saskatchewan
Fundersnot available
KeywordsStability (learning theory)Linear matrix inequalityLyapunov functionFunction (biology)Control theory (sociology)Computer scienceMatrix (chemical analysis)Gene regulatory networkGenetic algorithmMathematical optimizationMathematicsGeneNonlinear systemControl (management)BiologyGeneticsArtificial intelligencePhysics

Abstract

fetched live from OpenAlex

The study of the global stability is essential for designing and controlling genetic regulatory networks. Most existing results on this issue are based on linear matrix inequality (LMI) approach, which results in checking the existence of feasible solutions to high dimensional LMIs. In our previous study, we present several stability conditions for genetic regulatory networks with time-varying delays, based on M-matrix theory and the non-smooth Lyapunov function. In this paper, we design a smooth Lyapunov function and employ M-matrix theory to derive new stability conditions for genetic regulatory networks with time-varying delays. Theoretically, these conditions are less conservative than existing ones in some cases. For genetic regulatory networks with n genes and n proteins, these conditions become to check if an n×n matrix is an M-matrix, which is much easier than existing results. To illustrate the effectiveness of our theoretical results, two genetic regulatory networks are analyzed.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.003
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Simulation or modeling · Consensus signal: Simulation or modeling
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.003
Threshold uncertainty score0.010

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.003
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0010.000
Science and technology studies0.0000.001
Scholarly communication0.0010.001
Open science0.0010.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0030.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.009
GPT teacher head0.234
Teacher spread0.225 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designSimulation or modeling
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations4
Published2012
Admission routes1
Has abstractyes

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