Inhibition of Reagin-Mediated PCA Reactions in Monkeys and Histamine Release from Human Leukocytes by Human IgG <sub>4</sub> Subclass
Why this work is in the frame
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Bibliographic record
Abstract
Human myeloma proteins of IgG<sub>4</sub> subclass in contrast to myeloma proteins IgG<sub>1</sub>, IgG<sub>2</sub> and IgG<sub>3</sub>, were capable of blocking PCA reactions in monkeys mediated by human reaginic antibodies of IgE class. In addition to IgE, IgG<sub>4</sub> myeloma protein was also capable of sensitizing leukocytes from normal individuals and gave histamine release (HR) upon challenge with anti-human IgG<sub>4</sub>. Leukocytes from 11 allergic individuals and from 9 normal subjects sensitized with the serum of allergic patients, were capable of releasing histamine with anti-human IgG<sub>4</sub>, anti-human IgE, and the specific allergen. No response was obtained with anti-human IgG<sub>1</sub> and IgG<sub>3</sub> sera. Leukocytes from the normal individuals released histamine from 3 to 20% with anti-human IgG<sub>4</sub> and from 6 to 30% with anti-human IgE. Moreover, normal leukocytes sensitized with IgG<sub>4</sub> myeloma protein or a serum of an allergic patient heated at 56°C for 2 h, released a significant amount of histamine on challenge with anti-human IgG<sub>4</sub> whereas no response was obtained with anti-human IgE. The biological role of human IgG<sub>4</sub> in immediate hypersensitivity reactions is discussed in relation to human IgE.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it