Adult neural stem cells expressing IL-10 confer potent immunomodulation and remyelination in experimental autoimmune encephalitis
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Post-publication record
- Nature
- Retraction
- Reason
- Concerns/Issues about Data;Error in Image;Objections by Author(s);
- Date
- 9/16/2025 0:00
- Flagged by OpenAlex?
- Yes
Source: Retraction Watch, joined by DOI. OpenAlex records retraction as is_retracted, a boolean over a state space with at least four values, so it cannot express an expression of concern, a correction or a reinstatement — it reports them as false, which reads as “fine”.
Abstract
Adult neural stem cells (aNSCs) derived from the subventricular zone of the brain show therapeutic effects in EAE, an animal model of the chronic inflammatory neurodegenerative disease MS; however, the beneficial effects are modest. One critical weakness of aNSC therapy may be an insufficient antiinflammatory effect. Here, we demonstrate that i.v. or i.c.v. injection of aNSCs engineered to secrete IL-10 (IL-10-aNSCs), a potent immunoregulatory cytokine, induced more profound functional and pathological recovery from ongoing EAE than that with control aNSCs. IL-10-aNSCs exhibited enhanced antiinflammatory effects in the periphery and inflammatory foci in the CNS compared with control aNSCs, more effectively reducing myelin damage, a hallmark of MS. When compared with mice treated with control aNSCs, those treated with IL-10-aNSCs demonstrated differentiation of transplanted cells into greater numbers of oligodendrocytes and neurons but fewer astrocytes, thus enhancing exogenous remyelination and neuron/axonal growth. Finally, IL-10-aNSCs converted a hostile environment to one supportive of neurons/oligodendrocytes, thereby promoting endogenous remyelination. Thus, aNSCs engineered to express IL-10 show enhanced ability to induce immune suppression, remyelination, and neuronal repair and may represent a novel approach that can substantially improve the efficacy of neural stem cell-based therapy in EAE/MS.
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The record
- Venue
- Journal of Clinical Investigation
- Topic
- Neurogenesis and neuroplasticity mechanisms
- Field
- Neuroscience
- Canadian institutions
- Institute of Infection and Immunity
- Funders
- National Institutes of HealthMultiple Sclerosis SocietyMary E. Groff Surgical and Medical Research and Education Charitable TrustNational Multiple Sclerosis Society
- Keywords
- RemyelinationNeural stem cellBiologySecretionCell biologyStem cellMyelinImmunologyMultiple sclerosisNeuroscienceBiochemistryCentral nervous system
- Has abstract in OpenAlex
- yes