Bibliographic record
Abstract
When symptoms of childhood asthma are persistent and intrusive, no therapy restores control more reliably than the inhalation of topically effective corticosteroids. Within days, nocturnal symptoms of cough and wheeze become infrequent or disappear. When measured, lung function shows improvement and diurnal fluctuations in airway caliber show a decrease. In the ensuing weeks, daytime episodes of asthma will become less frequent, and laboratory measures of nonspecific bronchial hyperresponsiveness will improve. Underlying these changes is the restoration of normal airway histology. Bronchial biopsies in the patient with uncontrolled asthma show infiltration of the mucosa by eosinophils, disruption of the airway epithelium, and elaboration of tenacious mucous. This inflamed and edematous airway becomes more normal in appearance with several weeks of inhaled corticosteroid therapy such that bronchial biopsies in the steroid-treated patient appear normal or nearly so.1 Understandably, national and international guidelines for the management of pediatric and adult asthma postulate that inhaled corticosteroids are the most reliable foundation of pharmacotherapy in persistent disease.2 Regrettably, the parents of children with asthma and many clinicians who treat children with asthma are often reluctant to consider the use of inhaled corticosteroids.3 Many parental concerns are ill-informed and can be addressed by education. For example, parents may confuse the antiinflammatory corticosteroids for asthma care with the masculinizing steroids often abused by professional athletes or will express fears … Address correspondence to Kenneth R. Chapman, MD, MSc, FRCPC, FACP, FCCP, Asthma and Airway Centre, University Health Network, Toronto Western Hospital, Room 7-451 East Wing, 399 Bathurst St, Toronto, Ontario, Canada M5T 2S8. E-mail: kchapman{at}ca.inter.net
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.002 | 0.002 |
| Insufficient payload (model declined to judge) | 0.058 | 0.019 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".