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Record W2032090085 · doi:10.1016/j.hrthm.2010.08.016

Knock-in gain-of-function sodium channel mutation prolongs atrial action potentials and alters atrial vulnerability

2010· article· en· W2032090085 on OpenAlexafffund
Andreas Blana, Sven Kaese, Lisa Fortmüller, Sandra Laakmann, Dierk Damke, Kelly A. van Bragt, Jens Eckstein, Ilaria Piccini, Uwe Kirchhefer, Stanley Nattel, Günter Breithardt, Peter Carmeliet, Edward Carmeliet, Ulrich Schotten, Sander Verheule, Paulus Kirchhof, Larissa Fabritz

Bibliographic record

VenueHeart Rhythm · 2010
Typearticle
Languageen
FieldMedicine
TopicCardiac electrophysiology and arrhythmias
Canadian institutionsUniversité de MontréalMontreal Heart Institute
FundersCanadian Institutes of Health ResearchInterdisziplinäres Zentrum für Klinische Forschung, Universitätsklinikum WürzburgDeutsche Forschungsgemeinschaft
KeywordsMedicineSodium channelAction (physics)Gain of functionInternal medicineAtrial action potentialCardiologyMutationFunction (biology)ElectrophysiologySodiumCell biologyGeneticsRepolarizationGeneBiology

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.006
Threshold uncertainty score0.019

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0010.000
Science and technology studies0.0000.001
Scholarly communication0.0010.001
Open science0.0010.000
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0060.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.017
GPT teacher head0.291
Teacher spread0.274 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations53
Published2010
Admission routes2
Has abstractno

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