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Record W2032850900 · doi:10.1051/medsci/200622121013

La protéine prion ne se fait pas prier pour faire des agrégats moléculaires

2006· article· fr· W2032850900 on OpenAlexaff
Kevin Goggin, Xavier Roucou

Bibliographic record

Venuemédecine/sciences · 2006
Typearticle
Languagefr
FieldBiochemistry, Genetics and Molecular Biology
TopicPrion Diseases and Protein Misfolding
Canadian institutionsUniversité de Sherbrooke
Fundersnot available
KeywordsGynecologyMedicine

Abstract

fetched live from OpenAlex

1013 M/S n° 12, vol. 22, decembre 2006 controle de la douleur. De plus, les hormones sexuelles ont tres probablement un role a jouer sur les mecanismes excitateurs et inhibiteurs de la douleur. La testosterone aurait un role protecteur, role qui serait d’ailleurs phylogenetiquement conserve, car la testosterone est hypoalgesique non seulement chez les mammiferes, mais egalement chez certains oiseaux [9]. Les hormones sexuelles femelles, pour leur part, auraient un effet modulateur sur les mecanismes inhibiteurs de la douleur. On peut donc croire que certaines pathologies qui s’accompagnent de douleur chronique sont reliees a des deficiences hormonales produisant des deficiences de mecanismes de freinage de la douleur. Nous pouvons donc imaginer que, dans un futur pas tres lointain, un medecin devra non seulement evaluer les mecanismes excitateurs de la douleur chez un patient atteint de douleur chronique mais egalement l’etat hormonal de la personne. Nous ne sommes peut-etre plus tres loin des analgesiques roses ou bleus ! ‡ Is pain sexist? Endogenous pain mechanisms and sex hormones

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.046
Threshold uncertainty score0.155

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.001
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0010.000
Science and technology studies0.0010.001
Scholarly communication0.0020.001
Open science0.0010.001
Research integrity0.0020.002
Insufficient payload (model declined to judge)0.0460.021

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.023
GPT teacher head0.284
Teacher spread0.261 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations2
Published2006
Admission routes1
Has abstractyes

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