Transcriptional regulation of matrix metalloprotease gene expression in health and disease
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
The mammalian extracellular matrix (ECM) is a complex network of collagens, proteoglycans, glycoproteins, polysaccharides and other secreted proteins that plays fundamental structural and functional roles. In addition to its key function as an extracellular space-filling scaffold, the ECM is also implicated in the formation of important cell-cell and cell-ECM (i.e. juxtacrine) interactions that subsequently provide key regulatory signals that influence cellular proliferation and viability, differentiation, specialization and gene expression. Regulated turnover of the ECM, a process largely mediated by the tightly controlled matrix metalloprotease (MMP) enzyme family, is critical to a number of physiological processes involved in growth and development while aberrant turnover of matrix components is associated with congenital and metabolic diseases. The following review will focus on the transcriptional aspects of MMP gene expression, particularly in diseased states.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it