Resting Membrane Potential of Rat Plantaris Muscle Fibers After Prolonged Indirect Stimulation in Situ: Effect of Glucose Infusion
Bibliographic record
Abstract
The purpose of this study was to determine whether glucose infusion during prolonged indirect muscle stimulation (50 Hz for 200 ms every 2.7 s at 5 V) would have an effect on resting membrane potential (RMP). The RMP measured at Min 1 in the recovery period following stimulation of the rat plantaris muscle for 60 min in situ was significantly decreased in control rats, but was back to baseline values within 2 min. When glucose was infused ([glucose] approximately 10 mM), no change was observed in RMP, and muscle fatigue and the reduction in M-wave peak-to-peak amplitude were both attenuated. However, muscle force and the electrical properties of the membrane were deteriorated both in rats infused with glucose and in control rats at Min 2 during the recovery period, at a time when RMP was not modified. These observations suggest that the effect of increased circulating glucose on fatigue-associated reductions in muscle fiber RMP seems to be modest and short-lived. Therefore, the attenuating effect of elevated glucose on muscle fatigue responses could be through mechanisms other than those associated with maintenance of RMP during fatigue.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".