IS HEMOCONCENTRATION A MARKER OF SEVERITY?
Bibliographic record
Abstract
Background and Aims: Studies in humans suggest that hematocrit (HCT) could be a marker of severe pancreatitis. We showed previously in rats that hemoconcentration occurs in necrotizing but not in interstitial pancreatitis. The aim of this experiment was to evaluate whether hematocrit correlates with the severity of pancreatitis in rats. Methodology: Three models of induced acute pancreatitis with variable intensity were used. Mild pancreatitis (MP) was induced by 1 to 6 subcutaneous (s.c.) injections of cerulein in gelatin 12 μg/kg every 8 hours. Intermediate pancreatitis (IP) was induced by 1 s.c. injection of cerulein 100 μ/kg followed by 4 injections of 50 μg/kg every hour. Severe pancreatitis (SP) was induced by an intraperitoneal (i.p.) injection of L-arginine monohydrochloride 4.5g/kg. Measurements of HCT were done at times 0, 1, 2, 4, 8, 12, 16, 24 and 48 h post first injection. Groups of five rats were sacrificed at each time for blood collection and pancreas excision. Pancreas edema was evaluated by the percentage of water in the pancreas. Ratio of wet and dry weight was expressed as a percent (%) of water that represent pancreatic edema. Results: In SP, mean HCT peaked to 0.54 at time 2 h compared to 0.43 at 4 h for IP (basal value = 0.38). HCT was back to basal value after 12 h in both groups. HCT did not increase significantly in MP at anytime. Percent of water peaked to 67% and 68% at 4 h in IP and MP respectively. On the opposite, % of water did not change in SP during the first 16 h but increase to 66% after 24 h (basal value = 55%). No correlation was observed between HCT increase and % of pancreas edema. Conclusions: In these models of experimental pancreatitis, hemoconcentration is correlated with severity, supporting the hypothesis that HCT can be a marker of severity. Finally, no relation was found between HCT increase and pancreatic edema, suggesting that contrary to the traditional belief, pancreatic third space is not the cause of hemoconcentration. Supported by NSERC Canada.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".