Signet Ring Cell of the Non-Neoplastic Endometrium: A Case Report and Literature Review
Bibliographic record
Abstract
The observation of signet ring cells in endometrial biopsy results raises the possibility of the existence of a malignant primary or metastatic adenocarcinoma. We describe the case of a middle aged woman whose endometrial biopsy and curettage specimens contained signet ring cells indicating stromal decidual changes. Positive cytokeratin and CD10 immunohistochemistry staining results were revealed in the signet ring cells, features favoring a diagnosis of endometrial stromal cells showing decidual changes rather than a primary or metastatic endometrial neoplasm. Upon immunohistochemistry evaluation, they presented as vacuolated, decidualized endometrial stromal cells. Awareness of this morphologic change in the endometrial stroma can prevent overdiagnosis and overtreatment as primary or metastatic signet ring cell adenocarcinoma. Recognized by this morphologic feature, signet ring cells, or their close mimics, should not always be considered as a high grade or poorly differentiated adenocarcinoma. doi: http://dx.doi.org/10.4021/jcgo42e
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.002 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.006 | 0.004 |
| Science and technology studies | 0.001 | 0.002 |
| Scholarly communication | 0.002 | 0.002 |
| Open science | 0.002 | 0.001 |
| Research integrity | 0.003 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".