Behavior of Prions in the Environment: Implications for Prion Biology
Bibliographic record
Abstract
Prion diseases are infectious, potentially zoonotic neurodegenerative diseases of animals including humans that are inevitably fatal and are caused by prions. Prions are comprised of a misfolded isoform of the normal prion protein, PrP C , into the infectious conformation, PrP Sc Of the known prion diseases, chronic wasting disease (CWD) of deer, elk, and moose is emerging. CWD was first identified in captive deer in the front range of Colorado and Wyoming in the 1960s and has since been identified in captive and free-ranging cervids in 20 states, two Canadian provinces, and South Korea (for latest disease distribution please see http://www. nwhc.usgs.gov/disease_information/chronic_wasting_disease/index. jsp). While there is evidence of the spread of CWD along known cervid home ranges, the mechanism underlying the emergence of CWD in geographically isolated areas is not understood. The prevalence of CWD within an affected population is generally lower than 5%; however, there are reports of incidence rates that approach 50%. Transmission of CWD can occur horizontally or through CWDcontaminated environments, but the relative contribution of each mode in the overall transmission of CWD is unknown Since effective control measures are not available, it is likely that CWD will continue to spread in North America. The effect of this on the wellbeing of the cervid population and the risk of transmission to other species is not known.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".