Sertraline was effective and well tolerated for generalised social phobia
Bibliographic record
Abstract
Van Ameringen MA, Lane RM, Walker JR , et al. Sertraline treatment of generalized social phobia: a 20-week, double-blind, placebo-controlled study. Am J Psychiatry2001 Feb; 158 : 275 –81 [OpenUrl][1][CrossRef][2][PubMed][3][Web of Science][4] QUESTION: In patients with generalised social phobia, how safe and effective is sertraline? Randomised (unclear allocation concealment*), blinded {clinicians, patients, and outcome assessors*}†, with 20 weeks of follow up. 10 outpatient anxiety clinics in Canada. 204 patients who were 18–60 years of age (mean age 36 y, 56% men), met DSM-IV criteria for generalised social phobia lasting ≥1 year, and had a Clinical Global Impression (CGI) severity rating of ≤4. Exclusion criteria were uncontrolled illness precluding sertraline use, concomitant use of psychotropic or anti-anxiety medication, neuroleptics, serotonergic antidepressants, benzodiazepines, or β-blockers or clonidine; another primary axis I disorder or met criteria for agoraphobia, or panic, obsessive compulsive, … [1]: {openurl}?query=rft.jtitle%253DAmerican%2BJournal%2Bof%2BPsychiatry%26rft.stitle%253DAm.%2BJ.%2BPsychiatry%26rft.aulast%253DVan%2BAmeringen%26rft.auinit1%253DM.%2BA.%26rft.volume%253D158%26rft.issue%253D2%26rft.spage%253D275%26rft.epage%253D281%26rft.atitle%253DSertraline%2BTreatment%2Bof%2BGeneralized%2BSocial%2BPhobia%253A%2BA%2B20-Week%252C%2BDouble-Blind%252C%2BPlacebo-Controlled%2BStudy%26rft_id%253Dinfo%253Adoi%252F10.1176%252Fappi.ajp.158.2.275%26rft_id%253Dinfo%253Apmid%252F11156811%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/external-ref?access_num=10.1176/appi.ajp.158.2.275&link_type=DOI [3]: /lookup/external-ref?access_num=11156811&link_type=MED&atom=%2Febmental%2F4%2F3%2F91.atom [4]: /lookup/external-ref?access_num=000166761400018&link_type=ISI
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.006 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".