Case Reports of Three Hypothyroid Patients Requiring Very High Doses of Levothyroxine
Bibliographic record
Abstract
Majority of hypothyroid patients achieve and maintain euthyroidism on doses of levothyroxine in the range of 100 to 200 ug per day. This is a report of three patients with hypothyroidism requiring 300 - 450 ug of levothyroxine daily to be euthyroid. These comprised one case of central and two cases of primary hypothyroidism. Contributory factors to high doses of levothyroxine in the patients include use of efavirenz in one patient, morbid obesity and cimetidine therapy in another patient and sodium valproate treatment in the third patient. High doses of levothyroxine may be required to achieve euthyroidism in patients receiving efavirenz, sodium valproate and cimetidine. J Med Cases. 2014;5(8):452-454 doi: http://dx.doi.org/10.14740/jmc1822w
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.002 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.002 | 0.002 |
| Science and technology studies | 0.003 | 0.002 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.002 |
| Research integrity | 0.004 | 0.003 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".