Competing MYB networks as switches in primary and secondary metabolism in spruce
Bibliographic record
Abstract
BackgroundR2R3-MYB transcription factors are regulatory genes that have been linked to key aspects of plant development and secondary metabolism.They have been implicated in the transcriptional control of phenylpropanoid, and flavonoid metabolic pathways in model plant systems.However, in trees, knowledge is still limited about the role of R2R3-MYBs in such processes.Microarray transcript profiles (9K custom cDNA array) obtained from comparison between wild type and transgenic spruces that constitutively overexpressed Pinus taeda MYB1, MYB8 [1], and MYB14 [2] identified putative targets in flavonoid and phenylpropanoid metabolism.Cross-comparison of these data sets identified 70 sequences that were common to the three transgenic backgrounds: interestingly, 66 of these 70 sequences were co-expressed between PtMYB1 and PtMYB8 transgenics but produced opposite profiles with PtMYB14 transgenics.Pairwise comparisons between these transgenic data sets identified 121 additional sequences showing opposite profiles.Predicted annotations and KEGG classification showed that many of the sequences were linked to the metabolism of amino acids and carbohydrates as well as flavonoids, phenylpropanoids, and terpenoids.It was hypothesized that MYB1/MYB8 and MYB14 may be part of competing transcriptional networks for the regulation of primary metabolism and secondary metabolism.The opposite transcriptional responses might also support structural or defensive oriented response, respectively.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".