The effects of intracranial volume adjustment approaches on multiple regional MRI volumes in healthy aging and Alzheimer's disease

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No Canadian affiliation. An affiliation-only frame — the usual design — would never have seen this work. It is one of the works that make the case for inverting the frame.

Machine scores (provisional)

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Teacher spread

0.253 · how far apart the two teachers sit on this one work

Validation status

score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Abstract

In neurodegeneration research, normalization of regional volumes by intracranial volume (ICV) is important to estimate the extent of disease-driven atrophy. There is little agreement as to whether raw volumes, volume-to-ICV fractions or regional volumes from which the ICV factor has been regressed out should be used for volumetric brain imaging studies. Using multiple regional cortical and subcortical volumetric measures generated by Freesurfer (51 in total), the main aim of this study was to elucidate the implications of these adjustment approaches. Magnetic resonance imaging (MRI) data were analyzed from two large cohorts, the population-based PIVUS cohort (N = 406, all subjects age 75) and the Alzheimer disease Neuroimaging Initiative (ADNI) cohort (N = 724). Further, we studied whether the chosen ICV normalization approach influenced the relationship between hippocampus and cognition in the three diagnostic groups of the ADNI cohort (Alzheimer's disease, mild cognitive impairment, and healthy individuals). The ability of raw vs. adjusted hippocampal volumes to predict diagnostic status was also assessed. In both cohorts raw volumes correlate positively with ICV, but do not scale directly proportionally with it. The correlation direction is reversed for all volume-to-ICV fractions, except the lateral and third ventricles. Most gray matter fractions are larger in females, while lateral ventricle fractions are greater in males. Residual correction effectively eliminated the correlation between the regional volumes and ICV and removed gender differences. The association between hippocampal volumes and cognition was not altered by ICV normalization. Comparing prediction of diagnostic status using the different approaches, small but significant differences were found. The choice of normalization approach should be carefully considered when designing a volumetric brain imaging study.

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The record

Venue

Frontiers in Aging Neuroscience

Topic

Dementia and Cognitive Impairment Research

Field

Medicine

Canadian institutions

—

Funders

National Institute on AgingCanadian Institutes of Health ResearchUniversity of California, San DiegoGenentechNational Institutes of HealthIXICOSynarcSwedish Brain PowerServierKarolinska InstitutetEisaiStockholms Läns LandstingFondation pour la Recherche MédicaleNorthern California Institute for Research and EducationPfizerBiogenBioClinicaF. Hoffmann-La RocheUniversity of Southern CaliforniaMedpaceU.S. Department of DefenseEli Lilly and CompanyBristol-Myers SquibbNovartis Pharmaceuticals CorporationAlzheimer's Disease Neuroimaging InitiativeMeso Scale DiagnosticsAlzheimer's Association

Keywords

AtrophyNeuroimagingMagnetic resonance imagingBrain sizeCohortNeurodegenerationHippocampal formationPsychologyInternal medicineNeuropsychologyMedicineHippocampusNeurosciencePopulationCognitionDiseaseRadiology

Has abstract in OpenAlex

yes

API

/api/v1/works/W2035771001