Glomerular Basement Membrane in Experimental Nephrosis: X-Ray Diffraction and Electrophoretic Studies
Bibliographic record
Abstract
Basement membrane obtained from glomeruli of normal and nephrotic (anti-kidney serum) rats has been examined by microscope electrophoresis and X-ray diffraction techniques. Normal membrane had a mobility at pH 7.35 of 0.93 ± 0.12 µ/s/V/cm; the X-ray diffraction pattern resembled that of collagen, with an additional ring corresponding to a spacing at 2.25 Å. The membrane from nephrotic rats had a mobility of 0.69 ± 0.027 µ/s/V/cm, significantly lower than normal; the mobility was also decreased at pH of 2.25 and 8.75. The X-ray diffraction pattern showed several reflections corresponding to short spacings, not seen in the normal pattern, some of which disappeared on treatment of the membrane with collagenase. It is suggested that the changes in mobility and X-ray diffraction may be the result of loss of phospholipid and that the changes in diffraction pattern result from an increased ordering within the crystal lattice of both collagen and non-collagenous components.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".