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Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies

2009· review· en· 706 citations· W2037046278 on OpenAlex· 10.1038/ng.446

Why is this work in the frame?

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

Canadian affiliationAn author listed a Canadian institution. This is the only route the usual frame has.
Canadian funderA Canadian agency funded it. The work may carry no Canadian affiliation at all.

Classifier prediction

metacan-v1-d91a1de5be90

Predictions imitate two machine teachers. Scores are not calibrated prevalence probabilities.

Classifier candidate
MetaresearchMeta-epidemiology (broad)ObservationalMeta-analysisNot applicable
Classifier consensus
Observational
Teacher imitation scores

Codex

Meta-analysis0.522
Observational0.353
Meta-epidemiology (broad)0.027
Not applicable0.024
Metaresearch0.023
Other design0.003
Bench or experimental0.002
Meta-epidemiology (narrow)0.001
Theoretical or conceptual0.000
Bibliometrics0.000
Systematic review0.000
Open science0.000
Science and technology studies0.000
Research integrity0.000
Scholarly communication0.000
Qualitative0.000
Case report0.000
Simulation or modelling0.000
Randomized trial0.000
Non-randomized trial0.000

Gemma

Observational0.218
Not applicable0.147
Meta-analysis0.068
Metaresearch0.056
Meta-epidemiology (broad)0.008
Simulation or modelling0.001
Meta-epidemiology (narrow)0.001
Bibliometrics0.001
Open science0.001
Bench or experimental0.000
Research integrity0.000
Theoretical or conceptual0.000
Science and technology studies0.000
Qualitative0.000
Systematic review0.000
Case report0.000
Scholarly communication0.000
Randomized trial0.000
Non-randomized trial0.000

Machine scores (provisional)

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Opus teacher head0.039
GPT teacher head0.348
Teacher spread
0.309 how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Abstract

Bone mineral density (BMD) is a heritable complex trait used in the clinical diagnosis of osteoporosis and the assessment of fracture risk. We performed meta-analysis of five genome-wide association studies of femoral neck and lumbar spine BMD in 19,195 subjects of Northern European descent. We identified 20 BMD loci that reached genome-wide significance (GWS; P < 5 x 10(-8)), of which 13 map to regions not previously associated with this trait: 1p31.3 (GPR177), 2p21 (SPTBN1), 3p22 (CTNNB1), 4q2…

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