Impact of endocrine-disrupting chemicals on thyroid function and brain development
Bibliographic record
Abstract
Endocrine disrupting chemicals (EDCs) are synthetic or natural substances in the environment. EDCs have been shown to disrupt reproductive, developmental and other homeostatic systems by interfering with the synthesis, secretion, transport, metabolism and action of endogenous hormones including the thyroid hormone (TH) system. Since TH plays a critical role in brain development, the exposure to TH-system disrupting EDCs during development may have serious consequences. In this article, representative previous studies showing the effect of representative EDCs on the TH system are summarized. Then, the molecular mechanisms of action of polychlorinated biphenyls and polybrominated diphenyl ethers on the TH system are discussed further. Particularly, the effect of polychlorinated biphenyls and polybrominated diphenyl ethers on TH-mediated brain development is discussed. Our recent studies may provide a novel idea regarding the effect of EDCs on the TH system.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".