Coupling evanescent‐wave fluorescence imaging and spectroscopy with scanning probe microscopy: challenges and insights from TIRF–AFM
Why this work is in the frame
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Bibliographic record
Abstract
Abstract Recent work has demonstrated that imaging platforms based on the integration of total internal reflection fluorescence microscopy (TIRFM)/spectroscopy with scanning probe microscopy are well‐suited for investigations of biological phenomena, ranging from lipid bilayer dynamics and membrane protein assembly to cellular dynamics and structures. We have shown that this approach is particularly compelling for studies of protein‐membrane interactions. While this functional imaging strategy has proved to be very useful for studies of cell dynamics, and most recently, in the study of single‐molecule dynamics by TIRF‐AFM‐based force spectroscopy, a number of key challenges remain to be resolved. Copyright © 2006 John Wiley & Sons, Ltd.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it