The mRNA Closed-loop Model: The Function of PABP and PABP-interacting Proteins in mRNA Translation
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Translational control is an important means by whichcells govern gene expression. It provides a rapid responseto growth and proliferation stimuli and plays a role incontrolling feedback mechanisms in the cell. In systemswith little or no transcriptional control (e.g., reticulocytesand oocytes), translation is the predominant mode of regulation of gene expression (for review, see Mathews et al.2000). Initiation, the rate-limiting step of translation, isoften the target of translational control. All nuclear-transcribed eukaryotic mRNAs possess a 5′ cap (m7GpppN,where m is a methyl group and N is any nucleotide), andmost possess a 3′ poly(A) tail. The focus of this paper isthe role of the poly(A) tail and the poly(A)-binding protein (PABP) in translation initiation. Such an analysis requires a brief introduction of translation initiation and itscontrol...
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it