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Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia

2012· article· en· 526 citations· W2038676786 on OpenAlex· 10.1038/nm.2651

Why is this work in the frame?

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

Canadian funderA Canadian agency funded it. The work may carry no Canadian affiliation at all.

No Canadian affiliation. An affiliation-only frame — the usual design — would never have seen this work. It is one of the works that make the case for inverting the frame.

Machine scores (provisional)

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Opus teacher head0.008
GPT teacher head0.265
Teacher spread
0.257 · how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Abstract

No abstract. This is not a gap in this database — OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

The record

Venue
Nature Medicine
Topic
Epigenetics and DNA Methylation
Field
Biochemistry, Genetics and Molecular Biology
Canadian institutions
Funders
U.S. National Library of MedicineNational Cancer InstituteStand Up To CancerVlaamse regeringNational Institute of General Medical SciencesSchool of Medicine, New York UniversitySwim Across AmericaMinisterio de Ciencia e InnovaciónNational Institutes of HealthGenentechMinisterio de Economía y CompetitividadInstitut National de la Santé et de la Recherche MédicaleV Foundation for Cancer ResearchGeneralitat ValencianaDamon Runyon Cancer Research FoundationInstitute of Cancer ResearchNational Institute of Allergy and Infectious DiseasesHoward Hughes Medical Institute
Keywords
PRC2EZH2EpigeneticsBiologyPolycomb-group proteinsHistone H3Cancer researchHistoneGeneGeneticsCell biologyGene expressionRepressor
Has abstract in OpenAlex
no